Attaching and effacing pathogens: the effector ABC of immune subversion
نویسندگان
چکیده
منابع مشابه
Subversion of actin dynamics by EspM effectors of attaching and effacing bacterial pathogens
Rho GTPases are common targets of bacterial toxins and type III secretion system effectors. IpgB1 and IpgB2 of Shigella and Map of enteropathogenic (EPEC) and enterohemorrhagic (EHEC) Escherichia coli were recently grouped together on the basis that they share a conserved WxxxE motif. In this study, we characterized six WxxxE effectors from attaching and effacing pathogens: TrcA and EspM1 of EP...
متن کاملType Three Secretion System in Attaching and Effacing Pathogens
Enteropathogenic Escherichia coli and enterohemorrhagic E. coli are diarrheagenic bacterial human pathogens that cause severe gastroenteritis. These enteric pathotypes, together with the mouse pathogen Citrobacter rodentium, belong to the family of attaching and effacing pathogens that form a distinctive histological lesion in the intestinal epithelium. The virulence of these bacteria depends o...
متن کاملEspJ is a prophage-carried type III effector protein of attaching and effacing pathogens that modulates infection dynamics.
Enterohemorrhagic Escherichia coli, enteropathogenic E. coli, and Citrobacter rodentium are highly adapted enteropathogens that successfully colonize their host's gastrointestinal tract via the formation of attaching and effacing (A/E) lesions. These pathogens utilize a type III secretion system (TTSS) apparatus, encoded by the locus of enterocyte effacement, to translocate bacterial effector p...
متن کاملRegulation of type III secretion hierarchy of translocators and effectors in attaching and effacing bacterial pathogens.
Human enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC), and the mouse pathogen Citrobacter rodentium (CR) belong to the family of attaching and effacing (A/E) bacterial pathogens. They possess the locus of enterocyte effacement (LEE) pathogenicity island, which encodes a type III secretion system. These pathogens secrete a number of proteins into culture media, includi...
متن کاملHost immune status influences the development of attaching and effacing lesions in weaned pigs.
Attaching and effacing Escherichia coli (AEEC) has been associated with naturally occurring attaching and effacing (A/E) lesions in weaned pigs, and although A/E lesions have been experimentally reproduced in newborn piglets, such lesions have been much more difficult to induce in older conventional pigs. Hence, the aim of this study was to examine the effect of oral administration of dexametha...
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ژورنال
عنوان ژورنال: Future Microbiology
سال: 2020
ISSN: 1746-0913,1746-0921
DOI: 10.2217/fmb-2019-0274